The United States and Israel launched the most ambitious attack on Iran in decades on Saturday, and Israel said Supreme Leader Ali Khamenei had been killed in the operation.

Khamenei’s body has been found, a senior Israeli official told Reuters. Iran called the strikes unprovoked and illegal and responded with missiles fired at Israel and at least seven other countries, including Gulf states that host U.S. bases.

However, Iran’s Tasnim and Mehr News agencies reported Khamenei was ‘steadfast and firm in commanding the field’. Iran dismissed Israeli reports as ‘psychological warfare’.

U.S. President Donald Trump, who made the biggest foreign-policy gamble of his presidency after campaigning for reelection as a “peace president”, said the strikes were aimed at ending a decades-long threat from Iran and ensuring it could not develop a nuclear weapon.

Trump called on Iranian security forces to lay down their weapons and invited Iranians to topple their government once the bombing ended.

Israeli Prime Minister Benjamin Netanyahu said there were many signs indicating Khamenei “is no longer” and called on Iranians to finish the job. He said Khamenei’s compound had been destroyed, and Revolutionary Guard commanders and senior nuclear officials had been killed.

Three sources familiar with the matter said Iranian Defence Minister Amir Nasirzadeh and Revolutionary Guards commander Mohammed Pakpour were killed in the Israeli attacks. Iranian media had said Khamenei’s son-in-law and daughter-in-law were also killed.

Iran has confirmed 201 fatalities, including scores of students who were killed in Israeli strikes on a girls’ elementary school in Iran’s city of Minab. At least 747 people are said to have been injured so far.

Israel, US attack Iran

The United States and Israel carried out military strikes on Iran on Saturday, targeting its top leaders and plunging the Middle East into a conflict that President Donald Trump said would end a security threat to the U.S. and give Iranians a chance to topple their rulers.

Tehran called the attacks unprovoked and illegal, and responded by launching missiles at Israel and at several Gulf Arab allies of the United States that host American bases.

It promised a stronger response to come, with a senior Iranian Revolutionary Guards commander, Ebrahim Jabbari, saying it had so far used only “scrap missiles” and would soon unveil unforeseen weapons, state television reported.

Explosions rang out in nearby oil-producing Gulf Arab countries, which said they had intercepted missiles after Tehran warned it would strike the region if it was attacked.

The first wave of strikes in what the Pentagon named “OPERATION EPIC FURY” mainly targeted Iranian officials, a source familiar with the matter said, two days after indirect talks mediated by Oman failed to produce a breakthrough on Iran’s nuclear program.

Earlier today, an Israeli official said Iranian Supreme Leader Ayatollah Ali Khamenei and President Masoud Pezeshkian were both targeted, but the result of the strikes was not clear. A source with knowledge of the matter had earlier told Reuters that Khamenei was not in Tehran and had been transferred to a secure location.

‘No ship to pass through Strait of Hormuz’

An official from the European Union’s naval mission Aspides said on Saturday that vessels have been receiving VHF transmission from Iran’s Revolutionary Guards saying “no ship is allowed to pass the Strait of Hormuz”.

The Strait is the world’s most vital oil export route, which connects the biggest Gulf oil producers, such as Saudi Arabia, Iran, Iraq and the United Arab Emirates, with the Gulf of Oman and the Arabian Sea.

The official, who spoke to Reuters on condition of anonymity, said Iran had not formally confirmed any such order. Tehran has for years threatened to block the narrow waterway in retaliation for any attack on the Islamic Republic.

Trump says ‘bombs will be dropping everywhere’

In a video message published on social media, Trump cited Washington’s decades-old dispute with Iran, including the seizure of the 1979 U.S. embassy in Tehran, when students held 52 Americans hostage for 444 days, as well as a range of other attacks the U.S. has blamed on Iran since the 1979 Islamic revolution brought the clerics to power.

Trump, who had deployed vast U.S. military firepower in the region saying he hoped to force Iranian concessions in nuclear talks, said the “massive” operation was intended to ensure Tehran does not obtain a nuclear weapon and was aimed at “eliminating imminent threats from the Iranian regime”.

He urged Iranians to stay sheltered because “bombs will be dropping everywhere”. But he added: “When we are finished, take over your government. It will be yours to take. This will be probably your only chance for generations.”

Israeli Prime Minister Benjamin Netanyahu said the joint U.S.-Israeli attack “will create the conditions for the brave Iranian people to take their destiny into their own hands” and “remove the yoke of tyranny”. Defence Minister Israel Katz called it a pre-emptive strike to remove threats to Israel.

Iran’s clerical leaders were already in a difficult position after mass anti-government demonstrations in January, which led to a crackdown in which thousands of people were killed, the worst domestic unrest since the era of the 1979 revolution.

Protesters had again taken to the streets in recent days in remembrance of those killed the previous month.

Israeli military operations have killed some of Iran’s senior military officials and severely weakened several of Tehran’s once-feared proxy forces across the Middle East.

After Israel pounded Iran in a 12-day air war last June joined by the United States, the U.S. and Israel had warned that they would strike again if Iran pressed ahead with its nuclear and ballistic missile program. The threats were backed up in recent weeks by a U.S. military buildup in the region.

An Israeli defence official said the operation had been planned for months in coordination with Washington, and that the launch date was decided weeks ago.

Israel’s military said its Air Force had identified Iranian operatives in western Iran loading a missile unit and preparing to launch an attack. The Air Force struck the operatives and the launcher, preventing the attack, it said.

U.S. air defences intercepted and shot down a drone over a U.S. military base near Erbil in Iraq.

Missiles fired at Arab Gulf states

The renewed confrontation dimmed hopes of a diplomatic solution to Tehran’s nuclear dispute with the West. Oil markets have been closely watching the standoff between Washington and Tehran to try and determine if supplies will be impacted.

“If we don’t see signs of de-escalation over the weekend, risk premiums could still drive Brent up” by $10–$20 per barrel when markets reopen on Monday, said Jorge Leon, head of geopolitical analysis at Rystad Energy.

Iran, the third largest producer in the Organization of the Petroleum Exporting Countries, pumps about 4.5% of global oil supplies, and a far larger share is shipped past its coast through the strait leading out of the Gulf.

Iran’s Revolutionary Guards said all U.S. bases and interests in the region were within Iran’s reach and that Iran’s retaliation would continue until “the enemy is decisively defeated”. Iraq’s Iran-aligned armed group Kataib Hezbollah said it would soon attack U.S. bases in the region.

Saudi Arabia’s Crown Prince Mohammed bin Salman called United Arab Emirates President Sheikh Mohammed bin Zayed Al Nahyan to discuss the Iranian attacks on countries in the region and expressed solidarity, the UAE state news agency said.

Loud booms sounded in Abu Dhabi, capital of the United Arab Emirates, an oil producer and close U.S. ally, and several blasts were heard in the business capital Dubai.

Bahrain said the service center of the U.S. Fifth Fleet – base for American naval forces in the region – had been subjected to a missile attack. Video footage showed a thick grey plume of smoke rising from near the island state’s coastline as sirens wailed.

Qatar said it had downed all missiles targeting the country and that it had the right to respond. Kuwait confirmed a missile attack on a U.S. military base there.

An explosion was heard in Iran’s southeastern port city of Chabahar, Iranian state media reported.

Israel’s military did not immediately respond to a request for comment on the report of a strike at a primary school for girls in southern Iran, where Iranian state media reported 40 deaths.

In Israel, police said all holy sites were closed to visitors under national emergency guidelines after authorities announced several barrages of missiles were launched from Iran.

Global airlines cancelled flights across the Middle East and the attacks raised the prospect of oil prices rising. Some oil majors and trading houses suspended crude oil and fuel shipments via the Strait of Hormuz, four trading sources said.